In vitro maturation (IVM) consists of capturing immature ova and subsequently maturing them in a laboratory. After immersion in special cultures, these ova reach metaphase stage II (MII); they are fertilized and transferred to the pre-embryos and then the patient's uterus. Add details. There are many benefits to using IVM. Women with polycystic ovaries reap the most benefits, because they do not have to undergo ovarian stimulation for regular in vitro fertilization. This prevents the risk of an exaggerated ovarian response, which is called "ovarian hyperstimulation syndrome," a complication that occurs in approximately 5% of cases and can be very serious; it can even lead to a hospitalization.

The method can also be applied with women who present small follicles in the ultrasonography, but do not have the syndrome. IVM is also more affordable, approximately 40% to 50% less than other procedures. This is because it does not require gonadotropin (hormones used to stimulate the ovaries). The other advantage is that the follow-up is much simpler; the patient usually has fewer appointments at the fertilization clinic, which is more convenient for couples from cities and states where there are no specialized services. In reality, the concept of the technique has existed for several decades. However, more successful pregnancy rates were achieved only recently, through the development of high resolution ultrasonography equipment, appropriate needles, and especially specific culture methods for this purpose.

The Nilo Frantz Reproductive and Research Center has dedicated itself to implementing IVM since 2005. In 2007, the first IVM gestation took place, which culminated in August of 2008 with the first baby in Brazil to be born through use of the technique. This is one of many births that have been assisted by the Nilo Frantz Reproductive and Research Center. Though the treatment is simpler for the couple, it requires highly specialized professionals and a large investment in technology. The methodology is so complex that the first successful birth using this technique took place in England only one year prior, in 2007.